Pooled analysis of two phase 3 trials evaluating the effects of a novel combined oral contraceptive containing estetrol/drospirenone on bleeding patterns in healthy women - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35921872/
doi: 10.1016/j.contraception.2022.07.010. Online ahead of print. 1 Department of Obstetrics and Gynecology, University of Florida College of Medicine- Jacksonville, Jacksonville, Florida, USA. 2 Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh/Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA. 3 Gynecological Praxis St. Anna, Debrecen, Hungary. 4 Department of Obstetrics and Gynecology, University Hospital, Gent, Belgium.
Conclusion: E4/DRSP use results in a predictable bleeding pattern with limited unscheduled bleeding/spotting. Noncompliance and BMI affect bleeding patterns.