Women's and men's intake of omega-3 fatty acids and their food sources and assisted reproductive technologies outcomes
Source : https://www.ajog.org/article/S0002-9378(22)00250-2/pdf
Long-chain omega-3 fatty acids and their food sources have garnered interest as a potential nutrient with wide-range health benefits including fertility. To investigate the association of women's and men's intake...
Conclusions: Women’s consumption of omega-3 fatty acids and omega-3 rich-foods may improve the probability of conception by decreasing the risk of pregnancy loss. In addition, men’s intake of omega-3 fatty acids may influence semen quality.
Contraceptive drug, Nestorone, enhances stem cell-mediated remodeling of the stroke brain by dampening inflammation and rescuing mitochondria - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35341914/
Ischemic stroke remains a significant unmet need causing massive mortality and morbidity due to few treatment options with limited therapeutic window. The progestin Nestorone® (segesterone acetate) displays high affinity for...
Conclusion/Relevance: Nestorone exhibited increased stem cell proliferation and differentiation that was accompanied by rescue of the mitochondrial respiratory activity characterized by reduced mitochondrial reactive oxygen species, increased ATP, elevated mitochondrial deacetylase Sirtuin 3 (SIRT3), and a normalized ratio of acetyl-superoxide...
Persistent, Asymptomatic Colonization with Candida is Associated with Elevated Frequencies of Highly Activated Cervical Th17-Like Cells and Related Cytokines in the Reproductive Tract of South African Adolescents - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35348351/
doi: 10.1128/spectrum.01626-21. Online ahead of print. 1 Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Towngrid.7836.a, Cape Town, South Africa. 2 Seattle Children's Research Institute,...
Conclusion/Relevance: Our results suggest that Th17 cells are important for anti-Candida immunity in the human female genital tract and that prolonged vaginal Candida colonization may contribute to increased HIV risk in Sub-Saharan African adolescents by increasing HIV target cell frequencies and activation.
Changes in adverse pregnancy outcomes in women with advanced maternal age (AMA) after the enactment of China's universal two-child policy - Scientific Reports
Source : https://www.nature.com/articles/s41598-022-08396-6
The universal two-child policy (TCP; 2016) in China has affected many aspects of maternal-neonatal health. A tertiary hospital-based retrospective study (2011-2019) was used to find the association of these policy...
Conclusion/Relevance: In conclusion, the risk of GDM increased in women with AMA from the OCP period to the universal TCP period.
The effect of oral contraceptive use on cortisol reactivity to the Trier Social Stress Test: A meta-analysis
Source : https://www.sciencedirect.com/science/article/abs/pii/S030645302100500X?via=ihub
Cortisol response is blunted in OCP users relative to naturally cycling females. * Cortisol response is blunted in OCP relative to luteal phase. * No difference in cortisol responsivity between...
Conclusions: Results demonstrate that OCPs blunt cortisol reactivity relative to NC females. There was significant heterogeneity, except between OCP and follicular phase groups. Implications for research design and methodology are discussed.