Providing fertility-sparing tretment options for fibroid uterus
Source : https://doi.org/10.1089/jwh.2022.0368
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Discussion: At the same time, removal of this dynamic organ bears additional patient risk. In review of mortality data, compared with no surgery, hysterectomy without oophorectomy before 35 years was associated with an ‘‘increase in all-cause mortality (hazard ratio, 1.29; 95% confidence interval, 1.19–1.40); for surgery after 35 years of...
Discussion: This is the first study showing evidence that UL genomic subclasses may predict medical treatment.
Abnormal uterine bleeding patterns determined through menstrual tracking among participants in the Apple Women's Health Study
Source : https://www.ajog.org/article/S0002-9378(22)00839-0/fulltext
Publication History Publication stageIn Press Journal Pre-Proof Disclosure statement: CZ, SZ, UC, TF, LM and CC own Apple Inc. stock and CZ, SZ, SS, UC, TF, LM and CC are...
Conclusion: Participants with hyperthyroidism (PR: 1.34, 95% CI: 1.13, 1.59) and hypothyroidism (PR: 1.17, 95% CI: 1.05, 1.31) had a higher prevalence of AUB, as did those reporting endometriosis (PR: 1.28, 95% CI: 1.12, 1.45), cervical dysplasia (PR: 1.20, 95% CI: 1.03, 1.39) and fibroids (PR: 1.14, 95% CI: 1.00, 1.30).
Is total laparoscopic hysterectomy with longer operative time associated with a decreased benefit compared with total abdominal hysterectomy?
Source : https://www.ajog.org/article/S0002-9378(22)00797-9/fulltext
It is well known that, in general, total laparoscopic hysterectomy is associated with less perioperative morbidity compared with total abdominal hysterectomy. However, total laparoscopic hysterectomy is also associated with longer...
Conclusion: Our findings showed that there is no reasonable operative time at which total laparoscopic hysterectomy is associated with a higher rate of complications or longer length of stay than total abdominal hysterectomy.
Androgen Signaling in Uterine Diseases: New Insights and New Targets
Source : https://www.mdpi.com/2218-273X/12/11/1624/htm
Common uterine diseases include endometriosis, uterine fibroids, endometrial polyps, endometrial hyperplasia, endometrial cancer, and endometrial dysfunction causing infertility. Patients with uterine diseases often suffer from abdominal pain, menorrhagia, infertility and...
Conclusion: Androgen signaling is involved in many uterine physiological processes, and there are varying degrees of evidence for its role in benign uterine lesions and malignant progression. Androgens have been shown to be effective in many uterine diseases; however, the side effects of androgens have limited their use in women’s diseases....