Utility of the Diffusion Weighted Sequence in Gynecological Imaging: Review Article
Source : https://www.mdpi.com/2072-6694/14/18/4468/htm
Functional imaging with diffusion-weighted imaging (DWI) is a complementary tool to conventional diagnostic magnetic resonance imaging sequences. It is being increasingly investigated to predict tumor response and assess tumor recurrence....
Conclusion: DWI is a complementary MRI sequence that provides useful information. It has a wide range of applications in malignant and non-malignant gynecological conditions, playing an essential role in diagnosing or assisting in the diagnosis and providing supplementary information useful for their management. It is instrumental in...
A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase - Oncogenesis
Source : https://www.nature.com/articles/s41389-022-00425-3
Uterine leiomyomas, or fibroids, are the most common tumors in women of reproductive age. Uterine leiomyomas can be classified into at least three main molecular subtypes according to mutations affecting...
Discussion: In this study, we have identified a novel uterine leiomyoma subtype with biallelic mutations in genes involved in neddylation of the Cullin 3-RING E3 ligase.
Fibroids: yet another example of disparity in health? - BMC Medicine
Source : https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02528-5
BMC Medicine 20, Article number: 336 (2022) Cite this article 463 Accesses 3 Altmetric Metrics Providing rapid and effective reproductive and maternal health is a core hallmark of a well-functioning...
Discussion: Following the recent anniversary of Fibroid Awareness Month in July, we focus on this under-discussed disorder, female reproductive health and why further action is needed to improve outcomes.
Endometrial polyps-neoplastic lesions or not? Is it time to close the files? - Modern Pathology
Source : https://www.nature.com/articles/s41379-022-01162-z
Endometrial polyps (EMPs) are benign lesions with disorganized proliferation of endometrial glands histologically displaying irregularly shaped glands, hypercellular, hypocellular, or fibrous stroma as well as thick-walled blood vessels. In a...
Discussion: In summary, we do not feel that it is time to close the files on the pathogenesis of EMPs. Further investigations on the prevalence of possible driver mutations seem to be necessary. One other approach could be the investigation of a larger number of EMPs by immunohistochemistry for the overexpression of HMGA1 and HMGA2,...
Submucosal uterine fibroid | Radiology Case | Radiopaedia.org
Source : https://doi.org/10.53347/rID-66480
A well-circumscribed rounded mass lesion is noted in the submucosal region of the left lateral uterine wall, returning isointense signal (cf. myometrium) on T1, T2 and post-contrast images. The features...
Discussion: A well-circumscribed rounded mass lesion is noted in the submucosal region of the left lateral uterine wall, returning isointense signal (cf. myometrium) on T1, T2 and post-contrast images. The features are consistent with a submucosal uterine fibroid.