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Human Myometrial and Uterine Fibroid Stem Cell-Derived Organoids for Intervening the Pathophysiology of Uterine Fibroid - Reproductive Sciences

Uterine fibroids (UFs) (leiomyomas or myomas) are the most common clonal neoplasms of the uterus in women of reproductive age worldwide. UFs originate from myometrium consist of smooth muscle and ..... see more

Source : https://link.springer.com/article/10.1007/s43032-022-00960-9


Relevance: Gene expression analysis and structural features indicated the early onset of uterine fibrosis led to the accumulation of extracellular matrix suggesting the potential use of this model in better understanding of the pathophysiology associated with UFs and inventing novel therapeutics for the treatment of UFs.

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Pyomyoma in a primigravida at term: a case report

Pyomyoma is a rare complication of uterine fibroid occurring most commonly in pregnancy, post-partum, post-abortion, and post-menopausal periods. It results from infarction, necrosis and secondary infection of leiomyoma. We report ..... see more

Source : https://www.panafrican-med-journal.com/content/article/41/180/full/


Follow-up and outcome of interventions: she had two satisfactory postnatal clinic visits and she had no complaints. Histology report showed a degenerating leiomyoma with areas of cystic degeneration, necrosis, foci of suppuration and inflammatory cells infiltrations. There was no neoplastic changes. She was counselled on the possibility of...

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Current Strategies for Prevention of Infection After Uterine Artery Embolisation - CardioVascular and Interventional Radiology

Uterine artery embolisation (UAE) is a safe and effective procedure for symptomatic uterine fibroids with an estimated rate of post-operative intra-uterine infection of 0.9-2.5%. While rates of infection have remained ..... see more

Source : https://link.springer.com/article/10.1007/s00270-022-03158-3


Conclusion/Relevance: Uterine artery embolisation (UAE) is a safe and effective procedure for symptomatic uterine fibroids with an estimated rate of post-operative intra-uterine infection of 0.9–2.5%. While rates of infection have remained low over the past two decades, there is variation in infection prevention practices. Intra-uterine...

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Depot Medroxyprogesterone Acetate Use and the Development and Progression of Uterine Leiomyoma - PubMed

1 Epidemiology Branch and the Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, and Public Health and Epidemiology Practice, Westat, Durham, North Carolina; and the Department of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35576339/


Conclusion: Recent use of DMPA was associated with reduced leiomyoma development and increased leiomyoma loss. Such changes in early leiomyoma development in young women could delay symptom onset and reduce the need for invasive treatment.

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Individualized assessment of risk of complications following benign hysterectomy - PubMed

1 Department of Obstetrics and Gynaecology, Queen's University, Kingston, ON. 2 Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, ON. 3 Biostatistics Research Unit, University Health Network, Toronto, ON. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35504556/


Conclusion: This study identified several important risk factors for complications following hysterectomy. The utility of this data is important to help improve counselling for patients undergoing a hysterectomy and potentially optimize modified risk factors when identified preoperative.

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Dysmenorrhea in adolescents

Studies show that between 41% and 91.5% of young women, school-aged and university-aged, are affected by dysmenorrhea. Primary dysmenorrhea, which is caused by the production of prostaglandins, is defined as ..... see more

Source : https://www.sciencedirect.com/science/article/abs/pii/S1538544222000554?via=ihub


Relevance: Studies show that between 41% and 91.5% of young women, school-aged and university-aged, are affected by dysmenorrhea. Primary dysmenorrhea, which is caused by the production of prostaglandins, is defined as cramping pain in the lower abdomen and/or pelvis occurring just before or during menstruation, in the absence of other...

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Nephrogenic metaplasia in a female person with spinal cord injury: chronic irritation caused by Foley balloon was aggravated by a large uterine fibroid pressing upon the bladder wall for several years: a case report - Spinal Cord Series and Cases

Chronic irritation caused by urinary catheter may predispose to metaplastic changes in the bladder and very rarely, nephrogenic metaplasia. A 53-year-old lady with T-2 paraplegia and urethral catheter drainage for ..... see more

Source : https://www.nature.com/articles/s41394-022-00521-x


Discussion: Catheter reaction and nephrogenic metaplasia was found in the left superolateral wall of the bladder where the large uterine fibroid was pushing the balloon of the catheter against the bladder wall for more than seven years. The patient decided to undergo surgery to remove the large fibroid and thereby prevent further pressure...

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High grade sarcoma with chondrosarcomatous differentiation in primary uterine leiomyosarcoma; A rare case and review of literature

Leiomyosarcoma is a malignant mesenchymal tumor of smooth muscle origin with variable morphology. * Chondrosarcomatous differentiation in primary uterine leiomyosarcoma is quite uncommon. * Carcinosarcoma, a malignant biphasic tumor, is ..... see more

Source : https://www.sciencedirect.com/science/article/pii/S2352578921002095?via=ihub


Conclusion/Relevance: We report a case of a 68-year-old, African American woman who presented with postmenopausal bleeding …. Heterologous differentiation has rarely been described in metastatic or recurrent uterine LMS; however, a primary uterine LMS with chondrosarcomatous differentiation has not been reported previously.

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The trend in cesarean myomectomies and the risk of obstetrical complications in Korea - PubMed

CM should be considered a reliable and safe approach to prevent the need for another surgery for remnant leiomyoma. Herein, surgeons performed CM when uterine leiomyomas were large, of the ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35505300/


Conclusions: CM should be considered a reliable and safe approach to prevent the need for another surgery for remnant leiomyoma. Herein, surgeons performed CM when uterine leiomyomas were large, of the subserosal type, or few. Standardized treatment guidelines for myomectomy during CSs in pregnant women with uterine fibroids should be...

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Physiological tracer distribution and benign lesion incidental uptake of Al18F-NOTA-FAPI-04 on PET/CT imaging - PubMed

doi: 10.1097/MNM.0000000000001563. Online ahead of print. 1 The PET/CT Center, Department of Nuclear Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35506283/


Conclusion: This study provides a reference range for 18F-FAPI uptake in relevant organs and benign lesions. Benign lesion 18F-FAPI uptake may reduce 18F-FAPI PET/CT specificity.

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Concurrent Benign Metastasizing Leiomyoma in the Abdominal Wall and Pelvic Cavity: A Case Report and Review of the Literature

Benign metastatic leiomyoma (BML) is a histologically benign disease with invasive biological behavior. Most patients are women of childbearing age with a history of uterine leiomyoma. The progress of the ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fsurg.2022.842707/full


Conclusion/Relevance: Combined with the clinical data of this case and reviewing the relevant literature, this paper discusses the pathological characteristics, diagnosis, differential diagnosis, and treatment of BML.

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Rapid enlargement of pulmonary benign metastasizing leiomyoma with fluid-containing cystic change: a case report - Surgical Case Reports

Background Pulmonary benign metastasizing leiomyoma (PBML) is a rare disease that can occur in women with a history of uterine leiomyoma. Despite its benign histological features, like a malignancy, leiomyomas ..... see more

Source : https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-022-01444-3


Conclusion: Given the risk of rapid progression, we should carefully consider the surgical indications of fluid-containing PBML.

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Prolonged Cadmium Exposure Alters Migration Dynamics and Increases Heterogeneity of Human Uterine Fibroid Cells-Insights from Time Lapse Analysis

Cadmium (Cd) is one of the most prevalent environmental heavy metal contaminants and is considered an endocrine disruptor and carcinogen. In women with uterine fibroids, there is a correlation between ..... see more

Source : https://www.mdpi.com/2227-9059/10/4/917



Conclusion/Relevance: Cadmium (Cd) is one of the most prevalent environmental heavy metal contaminants and is considered an endocrine disruptor and carcinogen. In women with uterine fibroids, there is a correlation between blood Cd levels and fibroid tumor size. In this study, fibroid cells were exposed to 10 µM CdCl2 for 6 months and a...

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'I thought I had fibroids, and now I don't': a mixed method study on health-related quality of life in uterine sarcoma patients - Health and Quality of Life Outcomes

Background Uterine sarcomas are rare subtypes of primary urogenital tumours and need tailored treatment. This study aimed to examine the impact of diagnosis and treatment on health-related quality of life ..... see more

Source : https://hqlo.biomedcentral.com/articles/10.1186/s12955-022-01971-5



Conclusions: Uterine sarcoma patients experience a variety of concerns covering the physical, mental, and social domains of HRQoL that are in the main EORTC instruments, but not all of them. Combining cancer-generic, location- and sarcoma-specific items is recommended to assess HRQoL in this patient group.

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Analysis of Clinical Efficacy of Laparoendoscopic Single-Site Surgery for Uterine Fibroids

In order to determine the clinical efficacy of laparoendoscopic single-site surgery (LESS) for uterine fibroids (UFs), the study population comprises 65 patients who underwent hysteromyoma enucleation in our hospital from ..... see more

Source : https://www.hindawi.com/journals/jhe/2022/5606998/



Conclusion/Relevance: To sum up, LESS-M is more advantageous over MLS-M for the treatment of UFs and deserves to be popularized and applied clinically because it causes less physical damage to patients, with the ability to promote patients' postoperative recovery, reduce postoperative pain, and improve QOL and surgical satisfaction.

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Preoperative Differentiation of Uterine Leiomyomas and Leiomyosarcomas: Current Possibilities and Future Directions

The distinguishing of uterine leiomyosarcomas (ULMS) and uterine leiomyomas (ULM) before the operation and histopathological evaluation of tissue is one of the current challenges for clinicians and researchers. Recently, a ..... see more

Source : https://www.mdpi.com/2072-6694/14/8/1966



Conclusion/Relevance: In our review, we focus on the possible methods to diagnose uterine lesions effectively, including clinical signs and symptoms, laboratory tests, imaging methods, molecular aspects, available scales, and AI. In addition, considering costs and availability, we list the most promising methods to be implemented and...

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Uterine fibroids increase the risk of thyroid goiter and thyroid nodules - Scientific Reports

Uterine fibroid and benign thyroid disease are both common diseases in women. This study aimed to evaluate whether these diseases are related. We established the uterine fibroid group according to ..... see more

Source : https://www.nature.com/articles/s41598-022-10625-x



Conclusion: Although the mechanism is not well known, estrogen and iodide might be a link between uterine fibroids and thyroid goiters and nodules. Future studies that prospectively follow women with uterine fibroids across a lifetime are needed.

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Oriahnn: New Drug Approved for Treating Heavy Menstrual Bleeding in Women With Uterine Fibroids - PubMed

doi: 10.1177/10600280211015987. 1 Binghamton University School of Pharmacy and Pharmaceutical Sciences, Binghamton NY, USA. 2 Jefferson College of Pharmacy, Thomas Jefferson University, Philadelphia, PA, USA. doi: 10.1177/10600280211015987. 1 Binghamton University ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33998300/



Conclusions: Elagolix plus add-back therapy is effective in reducing menstrual bleeding associated with uterine fibroids. However, there are several warnings and precautions that must be considered.