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Conclusion: Urinary symptoms are often associated with uterine fibroids. The most frequently reported symptoms are overactive bladder symptoms and stress urinary incontinence. Urinary symptoms improve significantly after surgery.

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Discussion: This study illustrates that histotripsy is capable of fibroid ablation under certain pulsing parameters and warrants further investigation as an improved non-invasive ablation method for the treatment of leiomyomas.

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The Role of Cell Proliferation and Extracellular Matrix Accumulation Induced by Food Additive Butylated Hydroxytoluene in Uterine Leiomyoma

Leiomyoma is the most common benign uterine tumor in reproductive-age women. Increasing numbers of studies are focusing on the effects of environmental exposure on the incidence and progression of tumors. ..... see more

Source : https://doi.org/10.3390/nu13093074


Conclusion: Environmental exposure to BHT could be associated with several disease disorders and disadvantages. Using the ELT-3 rat leiomyoma cell model, the results shed light on BHT’s potential in enhancing leiomyoma cell proliferation, colony formation, and ECM accumulation in a mechanism that might involve modulation of PI3K/Akt and MAPK...

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A contrastive study on the clinical efficacy and safety of laparoscopic myomectomy and high intensity focused ultrasound in the treatment of uterine fibroidsn the treatment of uterine fibroids | Ren | Ginekologia Polska

Early publication date: 2022-05-30 Yingqiang Ren 1, Yutan Li 1, Yuanfang Pu 1 DOI: 10.5603/GP.a2022.0034 Department of Gynecology, The People's Hospital of Nanchuan, Chongqing, China ORIGINAL PAPERS Gynecology Early publication ..... see more

Source : https://journals.viamedica.pl/ginekologia_polska/article/view/86956


Conclusion: HIFU could improve the intraoperative efficacy and reduce the complications of patients with uterine fibroids and has excellent performance in improving clinical efficacy and prolonging PFS. HIFU can be used as an alternative to surgical treatment.

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Combined procedure of the transcervical radiofrequency ablation (TRFA) system and surgical hysteroscopy. Increased risk or safe procedure?

The advantage of transcervical radiofrequency ablation (TRFA) is that it is minimally invasive, incision-free, and treats a wide spectrum of fibroids, including those that are not accessible by surgical hysteroscopy ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186078/


Conclusions: Although TRFA is an approved method, it is not yet widely used worldwide. The combined procedure has been rarely used. The aim of our work is to show through our case series that transcervical radiofrequency ablation can be combined with surgical hysteroscopy for fibroid and/or endometrial resection without any additional risk.

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Simvastatin reduces plasma membrane caveolae and caveolin-1 in uterine leiomyomas - PubMed

1 Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. 2 Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35705139/


Significance: Our results identify caveolae and CAV1 as novel targets of simvastatin which may contribute to the recently described effects of simvastatin on ER-α signaling and plasma membrane trafficking.

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Case_series - Prioritizing bladder-sparing treatments in patients with urinary tract leiomyoma: A report of three cases and updated literature review - PubMed

Urinary tract leiomyomas are rare, benign mesenchymal tumors that are traditionally treated with complete surgical excision. We present three cases of urinary tract leiomyoma - two located in the bladder ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35704928/


Conclusion: Given the benign nature of leiomyomas and the overall low recurrence rate reported in the literature, bladder-sparing options should be emphasized when feasible, with active surveillance potentially applicable for highly select patients.

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Intramyometrial pregnancy presenting as abnormal uterine bleeding in perimenopausal female Kaul AR, Gupta UP, Kant D, Kant A - J Mid-life Health

CASE REPORT Year : 2022 | Volume : 13 | Issue : 1 | Page : 85-87 Intramyometrial pregnancy presenting as abnormal uterine bleeding in perimenopausal female Amrita Razdan Kaul ..... see more

Source : https://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2022;volume=13;issue=1;spage=85;epage=87;aulast=Kaul


Relevance: The aim of this case report is to consider this rare entity as a possible cause of AUB in perimenopausal female even in the pretext of negative pregnancy test.

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Radiomics and artificial intelligence in malignant uterine body cancers: Protocol for a systematic review

Introduction Uterine body cancers (UBC) are represented by endometrial carcinoma (EC) and uterine sarcoma (USa). The clinical management of both is hindered by the complex classification of patients into risk ..... see more

Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267727


Conclusion/Relevance: Uterine body cancers (UBC) are represented by endometrial carcinoma (EC) and uterine sarcoma (USa). The clinical management of both is hindered by the complex classification of patients into risk classes. This problem could be simplified through the development of predictive models aimed at treatment tailoring based on...

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Relugolix Combination Therapy for Uterine Leiomyoma-Associated Pain in the LIBERTY Randomized Trials - PubMed

1 Mayo Clinic, Rochester, Minnesota; the Carolina Woman's Research and Wellness Center, Durham, North Carolina; the Department of Clinical and Experimental Medicine, Unit of Obstetrics and Gynecology, Magna Graecia University ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35675604/


Conclusion: Over 24 weeks, relugolix-CT significantly reduced moderate-to-severe uterine leiomyoma-associated pain with a more pronounced effect on menstrual pain. These data support that relugolix-CT had clinically meaningful effects on women's experience of uterine leiomyoma-associated pain.

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Iatrogenic Parasitic Leiomyomas: A Late and Uncommon Complication After Laparoscopic Morcellation

Parasitic leiomyoma (PL) is an extremely rare variant of uterine leiomyomas that occurs outside of the uterus and can often present like intra-abdominal tumors. The aim of this study is ..... see more

Source : https://www.cureus.com/articles/94477-iatrogenic-parasitic-leiomyomas-a-late-and-uncommon-complication-after-laparoscopic-morcellation


Relevance: Parasitic leiomyoma (PL) is an extremely rare variant of uterine leiomyomas that occurs outside of the uterus and can often present like intra-abdominal tumors. The aim of this study is to report a case of PL and compare it with current literature.

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Are Deliveries by Inverted T-Incision on the Rise Due to Fibroids?: A Case Report

Fibroids are a common finding among women in their reproductive years. In pregnancy, many are incidentally diagnosed and if they are large, they often require careful monitoring concerning their size, ..... see more

Source : https://www.cureus.com/articles/89343-are-deliveries-by-inverted-t-incision-on-the-rise-due-to-fibroids-a-case-report


Conclusions/Relevance: Deliveries by inverted T-incisions have increased throughout the years, and this could be explained by the recent favoring of performing cesarean myomectomies, in large obstructing fibroids. Nowadays, with advanced preparations, myomectomies during cesarean section are safely and frequently performed when the benefits...

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Conclusions:
Women treated by TFA with the Sonata System for symptomatic uterine fibroids reported durable improvements in generic and fibroid-specific QOL, as well as clinically meaningful increases in QALYs over 3 years. Clinical Trials.gov ID: NCT02228174. (J GYNECOL SURG 38:143)


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Myomectomy during pregnancy; diagnostical dilemmas: two case reports and a systematic review of the literature - PubMed

Myomectomy in pregnancy, until this day, remains very controversial. We present two cases of successful antepartum myomectomies performed in the second trimester of gestation. In both cases, the initial suspected ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35264054/


Relevance:
Myomectomy in pregnancy, until this day, remains very controversial. We present two cases of successful antepartum myomectomies performed in the second trimester of gestation. In both cases, the initial suspected origin of these tumours was the ovaries.


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The Burden of Uterine Fibroids from the Perspective of US Women Participating in Open-Ended Interviews - PubMed

This study provides data on the symptoms experienced by women with HMB associated with UF, as well as the negative impacts of these symptoms as reported using their own words. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35415708/


Conclusions:
This study provides data on the symptoms experienced by women with HMB associated with UF, as well as the negative impacts of these symptoms as reported using their own words. The study findings confirm the significant burden associated with symptomatic UF.

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Uterine artery embolisation versus myomectomy for premenopausal women with uterine fibroids wishing to avoid hysterectomy: the FEMME RCT

This trial found that myomectomy resulted in greater improvement in quality of life at two years compared with uterine artery embolisation for women with uterine fibroids and at lower cost. ..... see more

Source : https://www.journalslibrary.nihr.ac.uk/hta/ZDEG6110

#/abstract

Conclusions: Among women with symptomatic uterine fibroids, myomectomy resulted in greater improvement in quality of life than did uterine artery embolisation. The differences in costs and quality-adjusted life-years are very small. Future research should involve women who are desiring pregnancy.


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Upper Cervical Leiomyoma in an Adolescent Male - PubMed

doi: 10.13107/jocr.2022.v12.i01.2594. 1 Department of Orthopaedics, D.Y. Patil University- School of Medicine, Navi Mumbai, Maharash-tra, India. 2 Department of Orthopaedics, Seth G.S. Medical College and K.E.M. Hospital, Mumbai, Maharashtra, India. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35611275/


Conclusion: Leiomyomas in the upper cervical spine is extremely rare in adolescent immunocom-petent male.

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Uterine artery embolization for pedunculated subserosal fibroids: a systematic review and meta-analysis - PubMed

1 Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. 2 Division of Vascular and Interventional Radiology, Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada. 1 Faculty of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35605818/


Conclusions: UAE for pedunculated subserosal fibroids has a low risk of adverse events and effectively reduces fibroid and uterine size.

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Analysis of Pregnancy Outcomes after Laparoscopic Myomectomy: A Retrospective Cohort Study

Objective . This study aimed to investigate the factors related to pregnancy outcomes after laparoscopic myomectomy. Methods . A retrospective review was conducted on 156 patients aged 18 to 45 ..... see more

Source : https://www.hindawi.com/journals/cmmm/2022/9685585/


Conclusions: The size of myoma may influence the pregnancy rate of patients after laparoscopic myomectomy. The number of fibroids can affect the incidence of placental adhesions during postoperative pregnancy.

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Metabolomic Profiling of Peripheral Plasma by GC-MS and Correlation With Size of Uterine Leiomyomas - PubMed

Background: Uterine leiomyomas are benign monoclonal tumors originating from the myometrium. Little information exists concerning metabolomics and the presence of leiomyomas. Objective: The present study evaluated circulating metabolites in the ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35611322/


Conclusion: There are different plasma metabolites levels of amino acids, fatty acids, and carbohydrates among patients with leiomyomas, most of them reduced, but some significantly increased in large leiomyomas, compared to leiomyoma-free patients.