Leiomyosarcoma is a malignant mesenchymal tumor of smooth muscle origin with variable morphology. * Chondrosarcomatous differentiation in primary uterine leiomyosarcoma is quite uncommon. * Carcinosarcoma, a malignant biphasic tumor, is more likely to be associated with homologous or heterologous differentiation. Primary uterine leiomyosarcoma (LMS) with chondrosarcomatous differentiation is extremely rare.
Conclusion/Relevance: We report a case of a 68-year-old, African American woman who presented with postmenopausal bleeding …. Heterologous differentiation has rarely been described in metastatic or recurrent uterine LMS; however, a primary uterine LMS with chondrosarcomatous differentiation has not been reported previously.