Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34977558/
A dapivirine-releasing silicone elastomer vaginal ring for reducing women's risk of HIV acquisition has recently been approved. A next-generation multipurpose vaginal ring releasing dapivirine and levonorgestrel is currently in development,...
Conclusion/Relevance: After extensive testing of the custom silicones and subsequent manufacture and testing (Shore M hardness, pot life, content assay, oscillatory rheology, mechanical testing) of rings containing both dapivirine and levonorgestrel, a lead candidate formulation was selected that was amenable to practical ring manufacture via...
Acceptability and Satisfaction of Contraceptive Vaginal Rings in Clinical Studies: A Systematic Review and Narrative Synthesis
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712726/
Introduction: Acceptability of and satisfaction with contraceptive methods are paramount for uptake and continuation. In the current context of multipurpose prevention of pregnancy and sexually transmitted diseases/HIV development, it is...
Conclusion: Positive aspects of acceptability of and satisfaction with CVRs were reported, but ring-related events and factors, which may affect long-term CVR use, deserve further study. More information is needed on actual experiences of women using CVRs, relationship aspects, male partner opinions, and contextual norms to better understand...
Use of estrogen supplementation is associated with higher quality of life scores in women with cystic fibrosis
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688700/
The association of estrogen supplementation use and quality of life in women with cystic fibrosis (CF) is not well characterized. In this cross-sectional study, women with CF completed quality of...
Conclusion/Relevance: This is the largest study to date investigating the association of estrogen supplementation and quality of life in women with CF. Prospective randomized studies are needed to clarify the association of estrogen supplementation and quality of life in women with CF.
Factors Influencing Contraceptive Use Among Sexually Active U.S. Middle and High School Students, 2015 to 2019
Objective The objective of this study is to see whether factors including the age of first sexual intercourse, sexual orientation, age at the time of survey administration, race/ethnicity, and sex...
Conclusion: We found significant differences in contraceptive and/or condom usage between students of different sexual orientations, sex, age of first sexual intercourse, age at the time of survey administration, and between different years studied. These differences could be attributed to differences in sex education, cultural background, and...
Factors Associated with Long-Acting Reversible Contraceptives Usage: Results from National Survey of Family Growth
Source : https://www.ajog.org/article/S0002-9378(21)02001-9/fulltext
Despite proven effectiveness and safety, long-acting reversible contraceptives (LARC) are underutilized. We sought to identify the factors associated with LARC usage in a reproductive population. We conducted a retrospective, cross-sectional...
Conclusion: Using a sample of nationally representative of women in the U.S., we identified several modifiable factors associated with current use of LARC. Considering the generalizability of our findings, these results may be used to plan interventional trials to increase LARC usage, especially among those with medical comorbidities.