Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34856119/
1 Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00290, Finland; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm 17165, Sweden. Electronic address: [email protected]. 2...
Conclusion/Relevance: For example, ethinyl estradiol, a common oral contraceptive, produced characteristic molecular and physiological effects, including increased levels of inflammation and impact on thyroid, cortisol levels, and pulse, that were distinct from other sources of variability observed in our study. In total, this work illustrates...
Combined Intranasal Insulin/Saxagliptin/Metformin Therapies Ameliorate the Effect of Combined Oral Contraceptive- (COC-) Induced Metabolic Syndrome (MetS) with a Major Target on Glucose Metabolism in Adult Female Wistar Rats - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34938803/
Objective: To evaluate the effect of the chronic use of combined oral contraceptives (COCs: ethinyl estradiol and levonorgestrel) on the indices of metabolic syndrome in adult female Wistar rats and...
Conclusions: The use of MET and SAX in combination with INI has been shown to reverse some indices of MetS. This study proposes a clinical phase to backup and ascertain these preclinical findings.
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Birth Control Spotlight4yrKey Points • Source: International Journal of Reproductive Medicine • Conclusions: “The use of MET [metformin] and SAX [saxagliptin] in combination with INI [insulin] has been shown to reverse some indices of MetS [metabolic Show More
Bone health and hormonal contraception - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34905875/
1 Operative Unit of Obstetrics and Gynecology, Pugliese-Ciaccio Hospital, Catanzaro, Italy - [email protected]. 2 Department of Obstetrics and Gynecology, Magna Græcia University of Catanzaro, Catanzaro, Italy. 1 Operative Unit of...
Conclusions: Since sex-steroid drugs induce variations in hormonal circulating concentrations, they may negatively affect bone metabolism. Contraceptive choice should be tailored evaluating any possible effect on bone health. Clinicians should always perform a precontraceptive counselling to identify any coexisting condition that may affect bone...
Oral contraceptive use by formulation and breast cancer risk by subtype in the Nurses' Health Study II: a prospective cohort study
Source : https://www.ajog.org/article/S0002-9378(21)02686-7/pdf
Oral contraceptive (OC) use has been associated with higher breast cancer risk; however, evidence on the associations between different OC formulations and breast cancer risk, especially by disease subtype, is...
Conclusions: Current OC use was associated with higher risk of invasive breast cancer regardless of disease subtype, though risk was comparable to never users 5 years after cessation. In analyses by progestin type, associations were observed for select formulations including levonorgestrel and norgestrel. Assessment of the associations for newer...
The use of serum segesterone acetate levels to assess adherence of trial participants with a contraceptive vaginal ring
Source : https://www.contraceptionjournal.org/article/S0010-7824(21)00477-7/fulltext
To determine the incidence of out-of-range segesterone acetate (NES) concentrations in participants of a pharmacokinetic/pharmacodynamic trial of a continuous use contraceptive vaginal ring (CVR) releasing NES and estradiol (E2). We...
Conclusion/Relevance: We found out-of-range NES concentrations, suggestive of improper use of a CVR associated with an increased risk of ovulation, with a direct relationship between the number of out-of-range events and the relative risk …. The results of this study support the use of out-of-range serum NES values as a marker of adherence in...